| O'Shea Jackson, Jr. | Actor |
| O. G. Anunoby | Basketball Player |
| O. Henry | Writer |
| O. J. Mayo | Basketball Player |
| O. J. Simpson | Athlete |
| O. R. Melling | Author |
| O. T. Fagbenle | Actor |
| O. T. Genasis | Musician |
| O. Winston Link | Photographer |
| Obiageli Ezekwesili | Public Servant |
| Obie Trice | Musician |
| Octave Mirbeau | Writer |
| Octavia E. Butler | Writer |
| Octavia Spencer | Actress |
| Octavian Paler | Writer |
| Octavio Paz | Poet |
| Oded Fehr | Actor |
| Odell Beckham, Jr. | Athlete |
| Odette Annable | Actress |
| Odeya Rush | Actress |
| Odilon Redon | Artist |
| Odion Ighalo | Athlete |
| Offset | Musician |
| Ofra Haza | Musician |
| Ofra Strauss | Businesswoman |
| Og Mandino | Author |
| Ogden Nash | Poet |
| Ok Taec-yeon | |
| Okieriete Onaodowan | Actor |
| Okky Madasari | Author |
| Oksana Baiul | Athlete |
| Oksana Masters | Athlete |
| Ol Parker | |
| Olaf Carlson-Wee | Businessman |
| Olafur Darri Olafsson | Actor |
| Olafur Eliasson | Artist |
| Olav Thon | Businessman |
| Ole Gunnar Solskjaer | Coach |
| Oleg Cassini | Designer |
| Oleg Deripaska | Businessman |
| Oleksandr Usyk | Athlete |
| Olesya Rulin | Actress |
| Olga Fonda | Actress |
| Olga Korbut | Athlete |
| Olga Kurylenko | Actress |
| Olga Tokarczuk | Writer |
| Olin Miller | Businessman |
| Olive Schreiner | Writer |
| Oliver Burke | Athlete |
| Oliver Cromwell | General |
| Oliver E. Williamson | Economist |
| Oliver Ellsworth | Lawyer |
| Oliver Evans | Inventor |
| Oliver Goldsmith | Poet |
| Oliver Hardy | Actor |
| Oliver Herford | Author |
| Oliver Hudson | Actor |
| Oliver Jackson-Cohen | Actor |
| Oliver Joseph Lodge | Physicist |
| Oliver Kahn | Athlete |
| Oliver Luck | |
| Oliver North | Soldier |
| Oliver Platt | Actor |
| Oliver Reed | Actor |
| Oliver Sacks | Scientist |
| Oliver Sim | Musician |
| Oliver St. John | Statesman |
| Oliver Stark | Actor |
| Oliver Stone | Director |
| Oliver Sykes | Musician |
| Oliver Tambo | Politician |
| Oliver Wendell Holmes, Jr. | Judge |
| Oliver Wendell Holmes, Sr. | Writer |
| Olivia Colman | Actress |
| Olivia Cooke | Actress |
| Olivia Culpo | Actress |
| Olivia d'Abo | Actress |
| Olivia De Havilland | Actress |
| Olivia Holt | Actress |
| Olivia Hussey | Actress |
| Olivia Munn | Actress |
| Olivia Newton-John | Musician |
| Olivia Thirlby | Actress |
| Olivia Wilde | Actress |
| Olivia Williams | Actress |
| Olivier Dahan | Director |
| Olivier Giroud | Athlete |
| Olivier Martinez | Actor |
| Olivier Megaton | Director |
| Olivier Messiaen | Composer |
| Olivier Theyskens | Designer |
| Ollie Watkins | Footballer |
| Olly Alexander | Musician |
| Olly Murs | Musician |
| Olof Palme | Politician |
| Olusegun Obasanjo | Statesman |
| Olympia Brown | Activist |
| Olympia Dukakis | Actress |
| Olympia Snowe | Politician |
| Om Malik | Writer |
| Om Puri | Actor |
| Omar Ahmad | Activist |
| Omar al-Bashir | Politician |
| Omar Amanat | Businessman |
| Omar Benson Miller | Actor |
| Omar Bongo | Statesman |
| Omar Dorsey | Actor |
| Omar Epps | Actor |
| Omar Khayyam | Poet |
| Omar N. Bradley | General |
| Omar Sharif | Actor |
| Omar Sy | Actor |
| Omar Torrijos Herrera | Soldier |
| Omari Hardwick | Actor |
| Omarion | Singer |
| Omarosa Manigault Newman | Celebrity |
| OMI | Musician |
| Omid Djalili | Actor |
| Oneohtrix Point Never | Musician |
| Oona Chaplin | Actress |
| Opal Tometi | Activist |
| Ophelia Lovibond | Actress |
| Oprah Winfrey | Entertainer |
| Oral Roberts | Clergyman |
| Oren Etzioni | Businessman |
| Oren Peli | Producer |
| Orhan Pamuk | Novelist |
| Ori Gersht | Photographer |
| Oriana Fallaci | Journalist |
| Orianthi | Musician |
| Origen | Theologian |
| Orison Swett Marden | Writer |
| Orla Brady | Actress |
| Orlando Aloysius Battista | Scientist |
| Orlando Bloom | Actor |
| Orlando Brown | Actor |
| Orlando Cepeda | Athlete |
| Orlando Gibbons | Composer |
| Orlando Jones | Comedian |
| Ornella Muti | Actress |
| Ornette Coleman | Musician |
| Orrin Hatch | Politician |
| Orson Bean | Actor |
| Orson F. Whitney | Clergyman |
| Orson Pratt | Theologian |
| Orson Scott Card | Writer |
| Orson Welles | Actor |
| Orville Redenbacher | Businessman |
| Orville Wright | Inventor |
| Ory Okolloh | Activist |
| Os Guinness | Author |
| Oscar | Footballer |
| Óscar Arias | Statesman |
| Oscar De La Hoya | Athlete |
| Oscar de la Renta | Designer |
| Oscar Fernandes | Politician |
| Oscar Hammerstein II | Musician |
| Oscar Hijuelos | Novelist |
| Oscar Isaac | Actor |
| Oscar Levant | Composer |
| Oscar Munoz | Businessman |
| Oscar Niemeyer | Architect |
| Oscar Nunez | Actor |
| Oscar Peterson | Musician |
| Oscar Pistorius | Athlete |
| Oscar Robertson | Athlete |
| Oscar Taveras | Athlete |
| Oscar Wilde | Poet |
| Oskar Kokoschka | Artist |
| Oskar Schindler | Businessman |
| Oskar Werner | Actor |
| Osman Rashid | Businessman |
| Ossie Davis | Actor |
| Oswald Chambers | Theologian |
| Oswald Mosley | Politician |
| Oswald Spengler | Philosopher |
| Oti Mabuse | Dancer |
| Otis Blackwell | Songwriter |
| Otis Redding | Musician |
| Otis Rush | Musician |
| Otis Williams | Musician |
| Ottessa Moshfegh | Author |
| Ottmar Hitzfeld | Coach |
| Otto Bauer | Writer |
| Otto Dix | Artist |
| Otto Frank | Celebrity |
| Otto Hahn | Scientist |
| Otto Heinrich Warburg | Scientist |
| Otto Hermann Kahn | Businessman |
| Otto Lilienthal | Aviator |
| Otto Loewi | Scientist |
| Otto Penzler | Editor |
| Otto Preminger | Director |
| Otto Rank | Psychologist |
| Otto Schily | Public Servant |
| Otto von Bismarck | Leader |
| Otto Wallach | Scientist |
| Otto Weininger | Philosopher |
| Ouida | Novelist |
| Ousmane Dembele | Athlete |
| Ovadia Yosef | Clergyman |
| Oveta Culp Hobby | Psychologist |
| Ovid | Poet |
| Owain Yeoman | Actor |
| Owen Arthur | Statesman |
| Owen Benjamin | Comedian |
| Owen Chamberlain | Scientist |
| Owen D. Young | Businessman |
| Owen Farrell | Athlete |
| Owen Feltham | Author |
| Owen Glendower | Royalty |
| Owen Hargreaves | Footballer |
| Owen Hart | Wrestler |
| Owen Jones | Journalist |
| Owen King | Author |
| Owen Paterson | Politician |
| Owen Wilson | Actor |
| Owen Wister | Writer |
| Oxana Chusovitina | Athlete |
| Ozuna | Musician |
| Ozwald Boateng | Designer |
| Ozzie Smith | Athlete |
| Ozzy Osbourne | Musician |
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